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Necrotizing enterocolitis associated with rotavirus infection.

B M Mogilner, A Bar-Yochai, A Miskin

    Israel Journal of Medical Sciences
    |October 1, 1983
    PubMed
    Summary

    Rotavirus infection may contribute to necrotizing enterocolitis (NEC) in premature infants. This study identified rotavirus in two infants with NEC, suggesting it as a potential infectious agent for this serious neonatal condition.

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    Area of Science:

    • Neonatal Medicine
    • Infectious Diseases
    • Gastroenterology

    Background:

    • Necrotizing enterocolitis (NEC) is a severe intestinal condition affecting neonates, particularly premature infants.
    • Infections, primarily bacterial, are known contributors to NEC development in compromised bowels.
    • Viral infections have been infrequently linked to NEC, leaving a gap in understanding potential etiological agents.

    Purpose of the Study:

    • To investigate the potential role of viral infections, specifically rotavirus, in the development of necrotizing enterocolitis (NEC) in premature infants.
    • To identify infectious agents associated with NEC cases within a Neonatal Intensive Care Unit (NICU) setting.

    Main Methods:

    • Case study observation of two premature infants diagnosed with NEC.

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  • Stool sample analysis for infectious pathogens, including rotavirus detection.
  • Epidemiological review of concurrent rotavirus diagnoses in the NICU population.

    • Main Results:

    • Rotavirus was detected in the stool samples of two premature infants who developed NEC.
    • During the study period, rotavirus was also diagnosed in 10 other infants admitted to the same NICU.
    • Both NEC cases occurred during the winter season, a common period for rotavirus circulation.

    Conclusions:

    • The findings suggest a potential association between rotavirus infection and the development of NEC in premature infants.
    • Rotavirus should be considered as a possible infectious agent contributing to NEC pathogenesis.
    • Further research is warranted to elucidate the mechanisms linking rotavirus to NEC.