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Analysis and microbiological stability of an isosorbide 50% mixture
Journal of Clinical and Hospital Pharmacy
|December 1, 1983
Summary
This study analyzes an isosorbide and sorbitol mixture for hydrocephalus treatment. Lead levels were assessed for infant safety, ensuring therapeutic efficacy and minimizing risks.
Area of Science:
- Pharmaceutical analysis
- Pediatric medicine
- Medical chemistry
Background:
- Hydrocephalus is a condition requiring effective treatments.
- Isosorbide and sorbitol mixtures are utilized in managing hydrocephalus.
- Ensuring the safety and quality of pharmaceutical preparations is crucial.
Purpose of the Study:
- To analyze the composition of an isosorbide-sorbitol mixture.
- To investigate the antimicrobial properties of the mixture.
- To determine lead content and assess its relevance for infant treatment.
Main Methods:
- Gas-liquid chromatography (G.L.C.) analysis for mixture composition.
- Antimicrobial property testing.
- Lead determination using relevant analytical techniques.
Main Results:
- The G.L.C. analysis confirmed the mixture's composition (50% w/v isosorbide, 5% w/v sorbitol).
- Antimicrobial properties of the isosorbide mixture were investigated.
- Lead levels in the mixture were determined and evaluated for infant safety.
Conclusions:
- The isosorbide-sorbitol mixture is suitable for hydrocephalus treatment.
- Lead levels are within acceptable limits for infant use.
- Quality control and safety assessment are vital for pediatric pharmaceuticals.