Persistent neonatal hypoglycaemia due to glucagon deficiency.

Area of Science:

• Pediatric Endocrinology
• Metabolic Disorders
• Neonatal Medicine

Background:

• Persistent severe hypoglycemia in newborns can lead to serious neurological complications.
• Glucagon is a key hormone regulating blood glucose levels.

Observation:

• A newborn presented with persistent severe hypoglycemia and convulsions.
• Diagnostic evaluation indicated a deficiency in glucagon.
• Delayed motor development was noted in the infant.

Findings:

• Treatment with zinc-protamine-glucagon injections twice daily effectively normalized blood glucose levels.
• The intervention successfully managed the severe hypoglycemia.

Implications:

• This case highlights the critical role of glucagon in neonatal glucose homeostasis.
• Early diagnosis and treatment of glucagon deficiency are crucial for preventing severe hypoglycemia.
• Further monitoring is necessary to address the delayed motor development.