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Intravenous fat tolerance in hepatic schistosomiasis.

M H Ghanem, M H Fahmy, M Said

Annals of Tropical Medicine and Parasitology

|April 1, 1978

Summary

Schistosomal patients exhibit a significantly slower lipid elimination rate after intravenous fat emulsion compared to healthy controls. This impaired triglyceride clearance suggests altered lipid metabolism in schistosomiasis.

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Area of Science:

Biochemistry
Clinical Medicine
Parasitology

Background:

Schistosomiasis is a parasitic disease affecting millions globally.
Altered lipid metabolism is increasingly recognized in chronic infections.
The impact of schistosomiasis on exogenous lipid processing remains unclear.

Purpose of the Study:

To investigate the in vivo elimination kinetics of an artificial fat emulsion in patients with schistosomiasis.
To compare lipid elimination rates between schistosomal patients and healthy controls.

Main Methods:

A single intravenous dose of artificial fat emulsion was administered to 13 schistosomal patients and 13 controls.
Triglyceride (TG) levels were measured at various time points post-injection.
Lipid elimination curves were analyzed for kinetic differences.

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Main Results:

Schistosomal patients showed significantly lower mean incremental TG values at 10 minutes post-injection compared to controls.
Lipid elimination followed zero-order kinetics in controls but exponential kinetics in schistosomal patients up to 120 minutes.
These findings indicate a delayed and altered clearance of exogenous lipids in schistosomiasis.

Conclusions:

Schistosomiasis is associated with impaired elimination of intravenously administered fat emulsion.
The altered triglyceride kinetics suggest a significant impact of the disease on lipid metabolism.
Further research is warranted to elucidate the underlying mechanisms and clinical implications of these metabolic disturbances.