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Intravenous fat tolerance in hepatic schistosomiasis
Annals of Tropical Medicine and Parasitology
|April 1, 1978
Summary
Schistosomal patients exhibit a significantly slower lipid elimination rate after intravenous fat emulsion compared to healthy controls. This impaired triglyceride clearance suggests altered lipid metabolism in schistosomiasis.
Area of Science:
- Biochemistry
- Clinical Medicine
- Parasitology
Background:
- Schistosomiasis is a parasitic disease affecting millions globally.
- Altered lipid metabolism is increasingly recognized in chronic infections.
- The impact of schistosomiasis on exogenous lipid processing remains unclear.
Purpose of the Study:
- To investigate the in vivo elimination kinetics of an artificial fat emulsion in patients with schistosomiasis.
- To compare lipid elimination rates between schistosomal patients and healthy controls.
Main Methods:
- A single intravenous dose of artificial fat emulsion was administered to 13 schistosomal patients and 13 controls.
- Triglyceride (TG) levels were measured at various time points post-injection.
- Lipid elimination curves were analyzed for kinetic differences.
Main Results:
- Schistosomal patients showed significantly lower mean incremental TG values at 10 minutes post-injection compared to controls.
- Lipid elimination followed zero-order kinetics in controls but exponential kinetics in schistosomal patients up to 120 minutes.
- These findings indicate a delayed and altered clearance of exogenous lipids in schistosomiasis.
Conclusions:
- Schistosomiasis is associated with impaired elimination of intravenously administered fat emulsion.
- The altered triglyceride kinetics suggest a significant impact of the disease on lipid metabolism.
- Further research is warranted to elucidate the underlying mechanisms and clinical implications of these metabolic disturbances.