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Development of a practical membrane lung system.

W C Helton, F W Johnson, J B Howe

    The Annals of Thoracic Surgery
    |July 1, 1978
    PubMed
    Summary
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    This study evaluated a compact membrane oxygenator for heart surgery. The Kolobow spiral-coil system proved safe and effective for short-term cardiopulmonary bypass procedures.

    Area of Science:

    • Cardiovascular Surgery
    • Biomedical Engineering
    • Medical Device Technology

    Background:

    • Extracorporeal circulation requires efficient blood oxygenation.
    • Development of compact and effective membrane oxygenators is crucial for modern cardiac surgery.
    • Existing systems may have limitations in terms of size, priming volume, or long-term efficacy.

    Purpose of the Study:

    • To assess a compact, single-pump membrane oxygenator system.
    • To evaluate its suitability for both short-term open-heart procedures and long-term extracorporeal support.
    • To optimize system components and operational protocols.

    Main Methods:

    • Development of a compatible disposable venous reservoir and compact mounting board.
    • Determination of acceptable priming volumes and safe operational modes.

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  • In vivo testing in 10 adult baboons and 9 human subjects (3 infants, 6 adults) using Kolobow spiral-coil membrane systems.

    • Main Results:

    • System components (venous reservoir, mounting board) were successfully developed.
    • Acceptable priming volumes and safe setup/operation modes were established.
    • The spiral-coil membrane system demonstrated safety and effectiveness in short-term cardiopulmonary bypass.

    Conclusions:

    • The evaluated compact membrane oxygenator system is suitable for short-term cardiopulmonary bypass.
    • Further research may be needed to fully establish its efficacy for long-term extracorporeal support.
    • The Kolobow spiral-coil membrane technology shows promise in cardiac surgical applications.