Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Visual evoked response testing method for neonatal rats.

R R Albee, J L Mattsson

Neurobehavioral Toxicology and Teratology

|September 1, 1983

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluation of the safety and nutritional equivalence of a genetically modified cottonseed meal in a 90-day dietary toxicity study in rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2007

Same author

An in vitro screening paradigm for extracts of whole foods for detection of potential toxicants.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2002

Same author

A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans.

Toxicological sciences : an official journal of the Society of Toxicology·2002

Same author

Reanalysis with optimized power of red blood cell acetylcholinesterase activity from a 1-year dietary treatment of dogs to chlorpyrifos.

Toxicology·2001

Same author

Do pesticides reduce our total exposure to food borne toxicants?

Neurotoxicology·2000

Same author

Chlorpyrifos: lack of cognitive effects in adult Long-Evans rats.

Neurotoxicology and teratology·2000

Visual evoked responses (VERs) in neonatal rats show rapid maturation, with latency decreasing significantly from 10 to 22 days. Factors like pup size and litter influenced these visual pathway development markers.

Area of Science:

Neuroscience
Developmental Biology
Ophthalmology

Background:

Visual evoked responses (VERs) are crucial for assessing visual pathway maturation.
Neonatal development involves significant changes in neural processing, including visual pathways.

Purpose of the Study:

To track the maturation of visual evoked responses in neonatal Fischer 344 rats.
To identify factors influencing the development of visual evoked responses, such as age, sex, and body weight.

Main Methods:

Recording visual evoked responses (VERs) using subcutaneous needle electrodes in pentobarbital-sedated neonatal Fischer 344 rats.
Tracking VER maturation across different age points: 10, 12, 14, and 22 days.
Analyzing latency to the first negative peak and correlating it with age, sex, and body weight.

Related Experiment Videos

Main Results:

Mean latency to the first negative peak significantly decreased with age, from 190.8 ms at 10 days to 39.4 ms by 22 days.
Larger pups and male pups exhibited shorter latencies.
Adjusting for body weight eliminated sex-based latency differences, and significant litter differences were observed.

Conclusions:

Visual evoked response latency demonstrates rapid maturation in neonatal rats within the first 22 days of life.
Factors such as pup size and litter origin significantly impact visual pathway maturation rates.
VER maturation is a reliable indicator of visual system development in early life stages.