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Renal involvement in Behçet's syndrome.
Archives of Internal Medicine
|July 1, 1978
Summary
Urinary abnormalities like proteinuria and microhematuria are common in Behçet's syndrome. These findings suggest a benign renal lesion, distinct from amyloidosis, affects patients with this condition.
Area of Science:
- Nephrology
- Rheumatology
- Internal Medicine
Background:
- Behçet's syndrome is a multisystemic inflammatory disorder.
- Renal involvement in Behçet's syndrome is not fully understood.
- Previous reports suggested amyloidosis as a cause of renal pathology.
Purpose of the Study:
- To investigate the prevalence and nature of urinary abnormalities in Behçet's syndrome.
- To determine if amyloidosis is the underlying cause of renal pathology.
Main Methods:
- Retrospective analysis of 77 Behçet's syndrome cases.
- Prospective evaluation of 51 patients from the initial cohort.
- Urinalysis, pyelography, and rectal biopsies were performed.
Main Results:
- 17 out of 33 patients in the retrospective study had abnormal urinalysis.
- An additional 8 patients showed urinary abnormalities in the prospective study, totaling 25.
- Abnormalities primarily consisted of proteinuria and/or microhematuria, often intermittent or persistent.
- Urinary sediment lacked leukocytes and casts; pyelography and rectal biopsies were unrevealing for amyloidosis.
Conclusions:
- A benign renal lesion is suggested in Behçet's syndrome.
- Amyloid deposition is unlikely to be the pathological substrate for these renal findings.