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Related Experiment Videos

Stereotyped responding by schizophrenic patients on a two-choice guessing task.

C D Frith, D J Done

    Psychological Medicine
    |November 1, 1983
    PubMed
    Summary

    Schizophrenia patients with negative symptoms exhibit stereotyped responses, indicating impaired behavioral control. This response pattern, seen in chronic schizophrenia, resembles effects of amphetamine, suggesting a higher-order control deficit.

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    Area of Science:

    • Neuroscience
    • Psychiatry
    • Cognitive Psychology

    Background:

    • Schizophrenia is a complex mental disorder affecting cognition and behavior.
    • Understanding response patterns in schizophrenia is crucial for diagnosis and treatment.
    • Previous research suggests alterations in behavioral control in various patient groups.

    Purpose of the Study:

    • To investigate response sequencing patterns in patients with schizophrenia and other neurological conditions.
    • To compare the behavioral stereotypy of different schizophrenia subtypes with control groups.
    • To explore the potential neurological underpinnings of observed response patterns.

    Main Methods:

    • Subjects performed a computerized task requiring them to guess the position of a visual stimulus.

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  • Response sequences were analyzed for randomness, stereotypy, and alternation patterns.
  • Participants included normal controls, patients with manic-depressive illness, senile dementia, and various schizophrenia subtypes (acute/chronic, positive/negative symptoms, defect state).

    • Main Results:

    • Normal controls, manic-depressive patients, and patients with senile dementia showed random response sequences.
    • Acute schizophrenic patients with positive symptoms also produced relatively random responses.
    • Schizophrenic patients with negative symptoms and chronic patients exhibited more stereotyped responses with alternations (LRLR).
    • Chronic schizophrenic patients with negative symptoms and intellectual deterioration displayed highly stereotyped responses with perseverations (LLLL).

    Conclusions:

    • Negative symptoms in schizophrenia, particularly in chronic cases with intellectual deterioration, are associated with severe response stereotypy.
    • This stereotypy, characterized by perseveration, is similar to that observed in animals after amphetamine administration.
    • The findings suggest an impairment in higher-order control processes that normally inhibit inappropriate response repetitions in schizophrenia.