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[Myxedema coma. Apropos of 8 cases]
Summary
This study reports on eight hypothyroid coma cases, detailing clinical, biological, and therapeutic aspects. Three patients died, highlighting the severity and challenges in managing this critical endocrine emergency.
Area of Science:
- Endocrinology
- Internal Medicine
- Critical Care Medicine
Context:
- Hypothyroid coma is a rare but life-threatening complication of untreated hypothyroidism.
- This report analyzes cases from a specific historical period (1971-1981).
- Understanding the clinical spectrum and outcomes is crucial for improving patient care.
Purpose:
- To describe the clinical, biological, and therapeutic characteristics of hypothyroid coma.
- To analyze mortality factors and discuss physiopathological mechanisms.
- To provide insights into the management of hypothyroid coma based on case series and literature.
Summary:
- Presents eight cases of hypothyroid coma, including clinical presentations, laboratory findings, and treatment strategies.
- Discusses key features such as hypothermia, cardiac and respiratory dysfunction, and hyponatremia.
- Reports a mortality rate of 37.5% (3 out of 8 patients), emphasizing the critical nature of the condition.
Impact:
- Highlights the significant mortality associated with hypothyroid coma.
- Informs clinical practice regarding the recognition and management of this endocrine emergency.
- Contributes to the understanding of the complex pathophysiology of hypothyroid coma.