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Phencyclidine exposure and the developing mouse: behavioral teratological implications.

J M Nicholas, E C Schreiber

    Teratology
    |December 1, 1983
    PubMed
    Summary
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    Perinatal phencyclidine (PCP) exposure in mice delayed reflex development and slowed growth in offspring. This indicates PCP

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Toxicology

    Background:

    • Perinatal exposure to drugs of abuse can impact offspring neurodevelopment.
    • Phencyclidine (PCP) is a dissociative anesthetic with known neurotoxic potential.
    • Understanding the specific effects of PCP on early development is crucial.

    Purpose of the Study:

    • To determine the effects of perinatal phencyclidine (PCP) exposure on the reflex development of offspring.
    • To investigate the impact of maternal PCP administration during gestation and/or lactation on neonatal development.

    Main Methods:

    • ICR Swiss mice dams were administered PCP (5, 10, 20 mg/kg) or saline during gestation and/or lactation.
    • Offspring were observed daily for reflex development using a modified Fox battery.

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  • Growth rates and righting times were assessed in exposed and control offspring.

    • Main Results:

    • PCP-exposed offspring exhibited delayed appearance of reflexes like walking and crawling.
    • A delay in the disappearance of the cross-extensor reflex was observed.
    • PCP exposure led to slower righting times and decreased growth rates in neonates.

    Conclusions:

    • Perinatal PCP exposure adversely affects the development of behavioral reflexes in mice.
    • Reflex ontogeny in neonates may serve as a sensitive indicator of behavioral teratology.
    • These findings highlight the neurodevelopmental risks associated with prenatal and postnatal PCP exposure.