Related Experiment Videos
Intracranial neoplasms in infants
Insights
This study analyzed 54 infant brain tumors (neoplasms) in Connecticut from 1935-1974. Medulloblastomas and ependymal neoplasms were most common, with vomiting and large head circumference being key indicators.
Area of Science:
- Pediatric Oncology
- Neuro-oncology
- Epidemiology of Childhood Cancers
Background:
- Primary intracranial neoplasms are rare but devastating in infants.
- Understanding the epidemiology of these tumors is crucial for diagnosis and treatment.
- Historical data provides valuable insights into disease patterns and outcomes.
Purpose of the Study:
- To describe the incidence, characteristics, and survival of primary intracranial neoplasms in infants.
- To analyze the relationship between tumor type, location, and patient outcomes.
- To present neurological function data for long-term survivors.
Main Methods:
- Retrospective analysis of 54 infant primary intracranial neoplasms diagnosed between 1935 and 1974 in Connecticut.
- Data collection included patient demographics, tumor histopathology, location, clinical presentation, and survival.
- Statistical analysis to determine frequencies, averages, and survival rates.
Main Results:
- Fifty-four cases occurred in infants aged 18 months or younger over 40 years.
- Medulloblastomas (30%) and ependymal neoplasms (16%) were the most frequent types.
- Common symptoms included vomiting; large head circumference was the most frequent physical finding. Average survival was 43 months.
Conclusions:
- Infant brain tumors exhibit specific histopathological and topographical distributions.
- Early identification of symptoms like vomiting and physical findings like increased head circumference is vital.
- Survival rates vary significantly based on tumor type and location, highlighting the need for tailored therapeutic strategies.
Abstract:
Fifty-four primary intracranial neoplasms occurred in infants (18 months of age or younger) in Connecticut during a 40-year period, 1935 to 1974. Thirty percent were medulloblastomas and 16% were ependymal neoplasms. An equal number of males and females were affected. Forty percent were located in the cerebellum, 37% in the cerebral hemispheres, and 17% in the brain stem. The most common symptom was vomiting. Abnormally large head circumference was the most common physical finding. Average survival was 43 months. Survival relative to histopathologic type and location of the neoplasm is discussed. Eighteen patients survived longer than one year and the level of neurological function of these longer survivors is presented.