Improved diagnostic yield of radionuclide angiography by quantitative phase analysis during resting angina and...

The reliability of quantitative phase analysis of radionuclide angiography in the detection of wall motion abnormalities has been investigated in 15 patients with angina at rest. All patients have been studied in the basal state, during spontaneous or ergonovine-induced ischemia and following isosorbide dinitrate acute i.v. administration in the resolution phase. Quantitative phase analysis provided a more sensitive index of impaired wall motion as compared to global ejection fraction changes. Isosorbide dinitrate rapidly and completely solved ischemic dyssynergies caused by coronary vasospasm.