Deep vein thrombosis during pregnancy. A prospective study

Area of Science:

• Obstetrics and Gynecology
• Vascular Medicine
• Thrombosis Research

Background:

• Deep venous thrombosis (DVT) is a significant concern during pregnancy.
• Atypical symptoms can delay diagnosis in pregnant patients.

Purpose of the Study:

• To investigate the presentation, diagnosis, and management of DVT in pregnant women.
• To evaluate the efficacy and safety of heparin therapy during pregnancy and postpartum.

Main Methods:

• Prospective study of 17 pregnant women with objectively diagnosed DVT.
• Diagnostic tools included phlebography, plethysmography, and thermography.
• Treatment involved self-administered subcutaneous heparin during pregnancy and lactation.

Main Results:

• The dominant symptom was diffuse lower abdominal and/or leg pain in 13/17 cases, often leading to diagnostic delays.
• Proximal (13/17) and left-sided (14/17) thrombi were predominant.
• Heparin therapy was administered via self-subcutaneous injection.

Conclusions:

• DVT should be suspected in pregnant women with uncharacteristic abdominal or leg pain.
• Objective verification of DVT is crucial before initiating treatment.
• Heparin is a safe and effective treatment, manageable with self-administration.
• Normal vaginal delivery is appropriate; early labor induction is not indicated.
• Postpartum treatment can continue with subcutaneous heparin or oral anticoagulants for 2-3 months.