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Pregnancy and venous thrombo-embolism
Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1983
Summary
Pregnancy-associated venous thrombosis predominantly affects the left leg and is linked to a defective fibrinolytic system, not coagulation changes. Diagnosis methods did not significantly alter findings in this study.
Area of Science:
- Obstetrics and Gynecology
- Vascular Medicine
- Hematology
Background:
- Pregnancy significantly increases the risk of venous thromboembolism.
- Understanding the long-term thrombotic process and hemostatic status is crucial for managing pregnancy-related venous thrombosis.
Purpose of the Study:
- To analyze the extension and localization of venous thrombosis during pregnancy.
- To investigate the relationship between thrombotic process and coagulation/fibrinolytic status post-thrombosis.
Main Methods:
- Retrospective analysis of 43 patients with venous thrombosis during pregnancy.
- Evaluation of coagulation and fibrinolytic status at least 6 months after thrombosis.
- Comparison between objectively and clinically diagnosed cases.
Main Results:
- Left-sided thrombi were predominant, more extensive, and proximal.
- Most thrombotic events initiated in the last two trimesters of pregnancy.
- Nineteen percent of patients exhibited a defective fibrinolytic system (reduced release capacity/vessel wall activity).
- Coagulation system showed minimal changes.
- No significant differences observed between clinical and objective diagnostic groups.
Conclusions:
- Defective fibrinolytic system is a key factor in pregnancy-associated venous thrombosis.
- Left-sided predominance and late-trimester onset are characteristic.
- Long-term evaluation reveals persistent hemostatic alterations, primarily in fibrinolysis.