Results of treatment with tamoxifen in oligozoospermic men

15 men, aged 32-42, with normo- and hypogonadotropic oligozoospermia were treated with the non-steroidal compound tamoxifen. The therapeutic period lasted for 6 month and tamoxifen was administered orally in a daily dose of 2 X 10 mg. The seminal and hormonal parameters were evaluated. A significant increase in sperm density was only found in responders. The compound showed no effect in men having a hypergonadotropic stage. The changes in endocrine parameters as levels of plasma testosterone, estradiol and gonadotropins were similarly affected in "responders" and "non-responders". Treatment with tamoxifen revealed no side effects regarding sexual behaviour, development of gynecomastia or nipple pains.