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Serum CK-MB isoenzyme after aortic and mitral valve replacements
Annals of Clinical Research
|January 1, 1983
Summary
Serum creatine kinase-MB (CK-MB) levels rise after cardiac surgery due to myocardial manipulation, not necessarily indicating infarction. Postoperative CK-MB levels correlate with aortic cross-clamping time but not recovery.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Cardiac surgery can cause myocardial manipulation and trauma, leading to the release of creatine kinase-MB (CK-MB) into the serum.
- Elevated CK-MB levels post-surgery are not always indicative of perioperative myocardial infarction.
Purpose of the Study:
- To investigate the significance of serum CK-MB levels following cardiac surgery.
- To determine if elevated CK-MB levels reliably indicate perioperative myocardial infarction.
Main Methods:
- Measured serum CK-MB isoenzyme levels in 76 patients 18 hours after aortic or mitral valve replacement.
- Included 13 control patients undergoing atrial septal defect closure.
- Correlated CK-MB levels with aortic cross-clamping time and electrocardiogram (ECG) voltage.
Main Results:
- Patients undergoing valve replacement had significantly higher mean CK-MB levels (95 +/- 103 U/l) compared to controls (45 +/- 39 U/l).
- Two patients with definite myocardial infarction showed high CK-MB values, but other patients with high CK-MB lacked ECG signs of infarction.
- CK-MB levels correlated with aortic cross-clamping time (r=0.39) and precordial ECG voltage (r=0.25).
Conclusions:
- Postoperative serum CK-MB elevation after cardiac surgery is common and not solely indicative of myocardial infarction.
- Findings suggest myocardial ischemia sensitivity during surgery, but postoperative recovery is not linked to CK-MB levels.