Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neural tube defects: clinical correlations.

R J Lemire

    Clinical Neurosurgery
    |January 1, 1983
    PubMed
    Summary

    Analyzing central nervous system (CNS) malformations involves classifying neural tube defects based on their developmental timing. This approach aids in correlating clinical findings with embryological events for better diagnosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The teratogenicity of N(omega)-nitro-L-ariginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, in rats.

    Reproductive toxicology (Elmsford, N.Y.)·1997
    Same author

    Epidemiology, etiologic factors, and prenatal diagnosis of open spinal dysraphism.

    Neurosurgery clinics of North America·1995
    Same author

    Aberrant morphogenesis of the central nervous system.

    Clinics in perinatology·1990
    Same author

    Management and long-term follow-up review of children with lipomyelomeningocele, 1952-1987.

    Journal of neurosurgery·1990
    Same author

    Pathophysiology of isolated lateral ventriculomegaly in shunted myelodysplastic children.

    Pediatric neurosurgery·1990
    Same author

    Anencephaly: its spectrum and relationship to neural tube defects.

    Journal of craniofacial genetics and developmental biology·1990

    Area of Science:

    • Developmental Neuroscience
    • Embryology
    • Clinical Neurology

    Background:

    • Central nervous system (CNS) malformations present complex diagnostic challenges.
    • Understanding the timing of embryonic development is crucial for classifying these defects.
    • Existing approaches to CNS malformation analysis require refinement for clinical utility.

    Purpose of the Study:

    • To present a practical framework for analyzing CNS malformations based on embryological timing.
    • To correlate clinical findings of neural tube defects with specific embryological events.
    • To differentiate between pre- and post-neurulation CNS malformations for diagnostic clarity.

    Main Methods:

    • Categorization of neural tube defects into those arising during neurulation versus those arising thereafter.
    • Application of this classification to both cranial and spinal lesions.
    • Correlation of clinical observations with embryological developmental stages.

    Main Results:

    • Pre-neurulation CNS malformations are typically not skin-covered and are amenable to prenatal diagnosis via amniocentesis.
    • Post-neurulation CNS malformations are skin-covered, exhibit diverse patterns, and have varied etiologies.
    • A subset of post-neurulation malformations overlaps with congenital tumors and are often not diagnosed prenatally.

    Conclusions:

    • Dividing CNS malformations based on neurulation timing provides a practical clinical correlation tool.
    • This embryological framework aids in interpreting clinical findings and understanding disease etiology.
    • Distinguishing between pre- and post-neurulation defects improves diagnostic accuracy and prenatal detection strategies.

    Related Experiment Videos