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[Mexiletine: electrophysiologic effects].

A Rizzo, F Sisto, R Fiorilli

    Giornale Italiano Di Cardiologia
    |November 1, 1983
    PubMed
    Summary

    Mexiletine (M.) showed minimal electrophysiological effects in patients, except for QTc shortening. It is not effective for supraventricular arrhythmias but may be safe for ventricular arrhythmias, with caution in specific conduction defects.

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    Area of Science:

    • Cardiology
    • Clinical Electrophysiology
    • Pharmacology

    Context:

    • Mexiletine is an antiarrhythmic drug.
    • Electrophysiological evaluations are crucial for assessing cardiac conduction.
    • Various cardiac conduction abnormalities necessitate careful drug selection.

    Purpose:

    • To evaluate the electrophysiological effects of intravenous Mexiletine.
    • To determine Mexiletine's efficacy and safety in different patient groups with cardiac conduction defects.

    Summary:

    • Intravenous Mexiletine (3 mg/Kg/B.W.) administration in 28 patients resulted in QTc interval shortening.
    • No significant changes were observed in other electrophysiological parameters, except for a prolonged H1-H2 interval in one patient with intrahisian conduction defect.
    • Mexiletine did not demonstrate significant effects on atrial or AV nodal conduction, suggesting limited utility for supraventricular arrhythmias.

    Impact:

    • Mexiletine may be safely used for ventricular arrhythmias in patients with atrial and/or AV nodal conduction defects.
    • Caution is advised when using Mexiletine in patients with sick sinus syndrome or significant intraventricular conduction defects.
    • The findings guide the clinical application of Mexiletine in managing cardiac arrhythmias.

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