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Plasmapheresis in thyroxine overdose: a case report.

M E May, P D Mintz, P Lowry

    Journal of Toxicology. Clinical Toxicology
    |July 1, 1983
    PubMed
    Summary
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    Thyrotoxicosis from excessive thyroid hormone medication can be delayed. Plasmapheresis did not significantly remove ingested thyroid hormone, but may reduce thyroxine

    Area of Science:

    • Endocrinology
    • Toxicology

    Background:

    • Thyrotoxicosis can result from medicinal thyroid hormone overdose.
    • The onset of toxicity may be significantly delayed.

    Observation:

    • A case of thyrotoxicosis due to massive thyroid hormone ingestion was treated with plasmapheresis.
    • The effectiveness of plasmapheresis in removing ingested thyroid hormone was evaluated.

    Findings:

    • Plasmapheresis removed an insignificant amount of thyroid hormone relative to the total ingested dose.
    • The plasma half-life of thyroxine (T4) appeared to be reduced in this acute, massive ingestion scenario.

    Implications:

    • Plasmapheresis is unlikely to be an effective treatment for acute massive thyroid hormone overdose.

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  • Further research is needed to understand the altered pharmacokinetics of thyroid hormone in massive overdose.