Modulation of guinea-pig peritoneal macrophage Fc receptor activity using D-penicillamine

The influence of D-penicillamine and 2,2'-pyridylisatogen tosylate upon guinea-pig peritoneal IgG Fc receptor activity is examined. D-penicillamine pretreatment of guinea-pig peritoneal cells is shown to selectively reduce the specificity of the interaction between 7s-human IgG and the guinea-pig macrophage Fc receptor population. In contrast, the drug did not influence the binding of guinea-pig 7s IgG2 nor the uptake of aggregated heterologous or homologous Immunoglobulin. Both D-penicillamine and 2,2'-pyridylisatogen tosylate are shown to influence particulate immune complex binding to pretreatment peritoneal cells.