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Disseminated intravascular coagulation in prostatic disease
Progress in Clinical and Biological Research
|January 1, 1976
Insights
Disseminated intravascular coagulation (DIC) can complicate prostate diseases, leading to bleeding during surgery or occurring chronically with prostate cancer. Understanding DIC
Area of Science:
- Urology
- Hematology
- Oncology
Background:
- Prostatic diseases, including benign prostatic hyperplasia and prostate cancer, can be complicated by Disseminated Intravascular Coagulation (DIC).
- DIC presents acutely during prostatectomy, causing significant bleeding, or chronically in advanced prostate cancer with metastases.
Observation:
- The abstract discusses the pathogenesis, diagnosis, clinical course, and treatment of DIC in the context of prostatic disease.
- Differentiation between DIC and primary fibrinolysis is crucial for appropriate management.
Findings:
- Acute DIC complicates prostate surgery with excessive intraoperative and postoperative bleeding.
- Chronic DIC is observed in prostate adenocarcinoma with hematogenous metastases.
Implications:
- Effective management of DIC is essential for improving outcomes in patients with complicated prostatic disease.
- This understanding aids in distinguishing DIC from other coagulopathies, guiding therapeutic strategies.
Abstract:
DIC may complicate prostatic disease either in its acute type during resection of the prostate causing excessive intra- or postoperative bleeding, or in its chronic type in cases with adenocarcinoma of the prostate with haematogenous metastases. Pathogenesis, diagnosis, clinical course, differentiation of the condition against consumption of clotting factors by primary fibrinolysis, and treatment are discussed. The course in four characteristic cases is demonstrated.