Synthesis and antimicrobial testing of certain oxadiazoline and triazole derivatives

The synthesis of some novel oxadiazolines and triazoles is described. Cyclization of nicotinic acid hydrazones using acetic anhydride afforded 2-substituted 3-acetyl-5-(3-pyridyl)-1,3,4-oxadiazolines. Likewise, when potassium dithiocarbazate--prepared from nicotinic acid hydrazide--was reacted with hydrazine hydrate, cyclization and production of 4-amino-3-(3-pyridyl)-5-mercapto[4H]-1,2,4-triazole was achieved. Ten new azomethine derivatives were prepared through the condensation between the latter amine and different aromatic aldehydes. The novel compounds were subjected to preliminary antimicrobial testing and the data obtained are summarized.