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[Familial nature of acute cerebral vasculopathies of the ischemic type]

G Cazzato, M Zorzon

    Rivista Di Neurologia
    |November 1, 1983
    PubMed

    Insights

    Family history of cerebrovascular accidents is higher in patients with transient ischemic attacks or non-embolic cerebral infarction. This increased risk is not solely due to higher rates of hypertension or diabetes.

    Area of Science:

    • Neurology
    • Cardiovascular Medicine
    • Genetics

    Context:

    • Investigating the familial aggregation of cerebrovascular diseases.
    • Examining the role of hypertension and diabetes as risk factors in these conditions.
    • Comparing family histories of patients with transient ischemic attacks (TIA) or non-embolic cerebral infarction (NECI) against a control group.

    Purpose:

    • To determine if cerebrovascular accidents (CVAs) and their risk factors (hypertension, diabetes) are more prevalent in the families of patients with TIA or NECI.
    • To assess the contribution of hypertension and diabetes to the observed familial risk of CVAs.

    Summary:

    • A retrospective study of 328 patients with TIA or NECI and a control group revealed a significantly higher frequency of CVAs in the patients' families.
    • While hypertension was significantly more common in patient families, diabetes rates were similar between patient and control groups.
    • The excess of CVAs in patient families could not be solely attributed to the higher prevalence of hypertension and diabetes.

    Impact:

    • Highlights a significant familial predisposition to cerebrovascular events beyond common risk factors.
    • Suggests potential genetic or shared environmental factors influencing CVA risk in families.
    • Informs genetic counseling and risk stratification for individuals with a family history of TIA or NECI.

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