Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differences in some erythroid regulatory parameters between two inbred mouse strains.

C D Dunn, L Gibson

    International Journal of Cell Cloning
    |October 1, 1983
    PubMed
    Summary

    Normal red blood cell production and destruction rates differ between mouse strains, impacting erythropoietin (Ep) levels and hematopoietic tissue sensitivity. These findings highlight strain-specific variations in erythropoiesis regulation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Human DNA recovery in the context of wildlife crime: Comparison of trace DNA collection methods from wildlife specimens.

    Forensic science international. Genetics·2025
    Same author

    Long-distance swimming by African lions in Uganda.

    Ecology and evolution·2024
    Same author

    Multigene profiles to guide the use of neoadjuvant chemotherapy for breast cancer: a Copenhagen Breast Cancer Genomics Study.

    NPJ breast cancer·2023
    Same author

    The impact a Mediterranean Diet in the third trimester of pregnancy has on neonatal body fat percentage.

    Journal of developmental origins of health and disease·2021
    Same author

    Exploring the impact of cultural beliefs in the self-management of type 2 diabetes among Black sub-Saharan Africans in the UK - a qualitative study informed by the PEN-3 cultural model.

    Ethnicity & health·2021
    Same author

    A peer support intervention for first-time mothers: Feasibility and preliminary efficacy of the mummy buddy program.

    Women and birth : journal of the Australian College of Midwives·2020

    Area of Science:

    • Hematology
    • Mouse models of erythropoiesis
    • Red blood cell kinetics

    Background:

    • Erythropoiesis, the process of red blood cell production, is tightly regulated.
    • Mouse strains exhibit genetic variations that can influence physiological processes.
    • Erythropoietin (Ep) is a key hormone regulating erythropoiesis.

    Purpose of the Study:

    • To compare normal erythropoiesis rates in two inbred mouse strains: CBA/Tr and C57Bl6/Tr.
    • To investigate the relationship between red blood cell turnover, serum Ep titers, and erythropoietin sensitivity in these strains.

    Main Methods:

    • Quantification of red blood cell production and destruction rates in vivo.
    • Measurement of serum erythropoietin (Ep) titers.
    • Assessment of in vitro erythropoietin sensitivity of hematopoietic tissue.

    Related Experiment Videos

    Main Results:

    • CBA/Tr mice demonstrated higher rates of red blood cell production and destruction compared to age-matched C57Bl6/Tr mice.
    • Serum Ep titers were significantly elevated in CBA/Tr mice relative to C57Bl6/Tr mice.
    • Hematopoietic tissue from CBA/Tr mice exhibited different in vitro erythropoietin sensitivities.

    Conclusions:

    • Differences in erythropoiesis operating points likely account for observed variations between mouse strains.
    • Strain-specific differences in erythropoiesis regulation influence erythropoietin levels and tissue sensitivity.
    • These findings provide insights into the genetic control of red blood cell homeostasis.