Mathematical analysis of antiserum titre and affinity in rabbits injected with 11 alpha OH-progesterone-hemisuccinate-BSA

A mathematical procedure is presented here to determine the behaviour of antiserum titre in rabbits, after repeated injections of 11 alpha OH-Progesterone-hemisuccinate-BSA. By means of methods recently applied to the time series, the peaks of maximum response were determined. A common behaviour of rabbits was revealed for the delay times in the response after each booster injection. The titre and affinity of antiserum were determined by means of a special method for mathematical treatment of data in RIA analysis, which gives directly such parameters with a statistical interpretation.