Lack of effect of alpha-methyldopa on pressor reflexes

The effects of three cumulative doses (20 mg/kg i.v.) of alpha-methyldopa were studied on pressor responses elicited by the stimulation of the central end of visceral or cutaneous afferences in the anaesthetized dog : vagus, superior laryngeal and saphenous nerves. As clonidine (previous results) alpha-methyldopa failed to modify these cardiovascular reflexes under our experimental conditions.