[Changes in the parameters of iron metabolism in acute poisoning with various drugs and solvents]

The study was aimed at evaluation of the dynamics of changes of ferrum balance parameters in patients acutely poisoned with some drugs and solvents. Altogether 19 persons were examined, in this 12 patients poisoned with drugs and 7 poisoned with solvents. The control group consisted of 20 persons. In all patients, on the first, second, third and last day of hospitalization, Fe concentration in blood serum was determined as well as latent capability of binding Fe by serum. Next, the total capability of Fe binding and coefficient of plasmatic transferine saturation with Fe were calculated. In case of drugs poisonings, statistically significant decrease of Fe concentration in serum on the second and third day of poisoning was found while no statistically significant differences were found in the other tested parameters during the first three days of hospitalization. In poisonings with ethylene glycol the tested parameters of ferrum balance are similar like the ones in drugs poisonings. The significant increase of Fe concentration was noted in cases of poisonings with such solvents as PER, TRI and TETRA.