Effect of indomethacin on rats with Grollman hypertension

Grollman hypertension was produced in 15 Sprague-Dawley rats, and chronic 46-week hypertension was observed in these rats. Weekly subcutaneous injections of 1.44 mg indomethacin resulted in significant reduction of the systolic blood pressure 1 h after the injection (p less than 0.001). There was no change in the blood pressure following treatment with indomethacin in the 6 normotensive control rats. Light microscopic examinations revealed that adrenal and cardiac tissues were free of serious toxic indomethacin effects. Liver tissue examination showed slight degenerative changes in the indomethacin-treated animals.