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[Erythrocyte changes in diabetes].

G Pozza, O Carandente

    La Ricerca in Clinica E in Laboratorio
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Diabetes mellitus alters erythrocyte glucose metabolism, increasing red blood cell rigidity. This study analyzes key metabolic factors and presents new data on sorbitol

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    Area of Science:

    • Biochemistry
    • Hematology
    • Diabetology

    Background:

    • Diabetes mellitus is associated with altered erythrocyte (red blood cell) function.
    • Increased red blood cell rigidity is a known complication in diabetic patients.

    Purpose of the Study:

    • To investigate the link between glucose metabolism changes in erythrocytes and their increased rigidity in diabetes mellitus.
    • To analyze the role of glycolytic intermediates, adenosine, pyridine nucleotides, and insulin in erythrocyte alterations.
    • To present original data on intracellular sugar levels, specifically sorbitol, and their contribution to rheological changes.

    Main Methods:

    • Literature review of factors influencing erythrocyte metabolism and function in diabetes.
    • Analysis of existing data on glycolytic intermediates, adenosine, pyridine nucleotides, and insulin.

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  • Presentation of original experimental data on intracellular sugar levels and erythrocyte rheology in diabetic subjects.

    • Main Results:

    • Specific alterations in erythrocyte glucose metabolism contribute to increased cell rigidity in diabetes mellitus.
    • Intracellular accumulation of certain sugars, notably sorbitol, plays a role in these rheological changes.
    • Metabolic intermediates and signaling molecules like adenosine and insulin are implicated in the observed erythrocyte dysfunction.

    Conclusions:

    • Glucose metabolism dysregulation in erythrocytes is a significant factor in the increased red blood cell rigidity observed in diabetes mellitus.
    • Sorbitol accumulation and other metabolic shifts contribute to impaired erythrocyte deformability and rheology.
    • Understanding these erythrocyte alterations is crucial for managing diabetic complications.