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[Hemorrheological changes in cerebrovascular disease].

C Fieschi, C Iadecola

    La Ricerca in Clinica E in Laboratorio
    |January 1, 1983
    PubMed
    Summary

    High blood viscosity, often caused by elevated hematocrit, increases stroke risk. Interventions like venesection and hemodilution may help manage this risk and improve cerebral blood flow.

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    [Not Available].

    Italian journal of neurological sciences·2016

    Area of Science:

    • Neurology
    • Hematology
    • Vascular Medicine

    Context:

    • High blood viscosity is increasingly recognized as a significant factor in ischemic cerebrovascular diseases.
    • Elevated hematocrit (above 46%) is linked to increased risk of cerebral infarction.
    • Reduced cerebral blood flow is observed in patients with high hematocrit.

    Purpose:

    • To review the role of high blood viscosity and hematocrit in cerebrovascular diseases.
    • To explore the potential of venesection and hemodilution in managing these conditions.

    Summary:

    • Clinical studies show elevated hematocrit increases cerebral infarction risk.
    • Venesection (blood removal) can normalize cerebral blood flow in high hematocrit patients.
    • Hemodilution has shown promise in reducing infarct size in experimental brain ischemia.

    Impact:

    • Venesection is proposed as a preventive measure for high-risk individuals.
    • Hemodilution is suggested as a treatment for acute cerebral ischemia.
    • Further research is needed to fully clarify the mechanisms and clinical significance of high blood viscosity in cerebral ischemia.

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