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Cholangiography in rabbits before and after papillotomy
Scandinavian Journal of Gastroenterology
|November 1, 1983
Summary
Endoscopic papillotomy (EPT) can cause sphincter of Oddi dysfunction, impairing gallbladder and bile duct visualization. Intravenous cholangiography may be unreliable after EPT due to this sphincter insufficiency.
Area of Science:
- Gastroenterology
- Hepatobiliary Surgery
- Diagnostic Imaging
Background:
- The sphincter of Oddi regulates bile and pancreatic juice flow.
- Endoscopic papillotomy (EPT) is a procedure to treat bile duct stones and other conditions.
- The impact of EPT on biliary system imaging requires further investigation.
Purpose of the Study:
- To evaluate the effect of EPT on gallbladder and bile duct visualization using intravenous cholangiography (IVC).
- To assess the functional integrity of the sphincter of Oddi after EPT.
Main Methods:
- New Zealand white rabbits underwent EPT.
- Intravenous cholangiography (IVC) was performed before and after EPT.
- Reflux cholangiography was used to assess sphincter function post-EPT.
Main Results:
- Gallbladder opacification decreased significantly after EPT (1/7 animals vs. 6/6 controls).
- Bile duct visualization was compromised post-EPT (0/7 animals vs. 5/6 controls).
- Reflux cholangiography confirmed free reflux from the duodenum, indicating sphincter of Oddi insufficiency.
Conclusions:
- EPT leads to insufficiency of the sphincter of Oddi.
- Intravenous cholangiography may be unreliable for assessing the gallbladder and bile ducts after EPT.