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Silicone as coating material for hemoperfusion.

O Otsubo, M Nomura, T Watanabe

    Transactions - American Society for Artificial Internal Organs
    |January 1, 1983
    PubMed
    Summary
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    This study introduces silicone-coated activated charcoal for direct hemoperfusion (DHP). This new material minimizes blood component loss and maintains adsorption capacity, improving DHP therapy effectiveness.

    Area of Science:

    • Biomaterials Science
    • Nephrology
    • Medical Device Engineering

    Background:

    • Direct hemoperfusion (DHP) using activated charcoal is effective but faces challenges.
    • Existing methods suffer from reduced blood component levels and diminished adsorbent capacity due to coating layers.

    Purpose of the Study:

    • To develop and evaluate a novel silicone-coated activated charcoal for DHP.
    • To assess its impact on blood components and adsorption capacity compared to uncoated and PHEMATM-coated charcoal.

    Main Methods:

    • Developed thermosetting resin-derived activated charcoal coated with silicone.
    • Conducted in vitro adsorption capacity tests.
    • Performed 3-hour DHP in blood, analyzing changes in leukocyte and platelet counts.
    • Utilized scanning electron microscopy (SEM) to examine blood component adsorption on the charcoal surface.

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    Main Results:

    • Silicone-coated charcoal showed reduced reduction in leukocyte and platelet counts compared to uncoated charcoal.
    • Variations in blood cell counts were minimal with silicone-coated charcoal during DHP.
    • SEM analysis revealed very slight adsorption of blood components on the silicone-coated surface.
    • Adsorption of amino acids and related compounds was comparable to uncoated charcoal, indicating minimal loss of adsorption capacity.

    Conclusions:

    • Silicone-coated activated charcoal demonstrates excellent applicability for DHP therapy.
    • The novel coating effectively preserves blood components and maintains significant adsorption capabilities.
    • This material offers a promising advancement for improving DHP treatment outcomes.