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Related Experiment Videos

Immunopathologic aspects in human onchocercal lymphadenitis.

P Racz, K Tenner-Racz, B Luther

    Bulletin De La Societe De Pathologie Exotique Et De Ses Filiales
    |November 1, 1983
    PubMed
    Summary
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    Onchocerciasis involves degenerated microfilariae in lymph nodes, with eosinophils and macrophages playing key roles. Immune cells like mast and plasma cells, along with IgE and IgG, are significantly involved in the immune response.

    Area of Science:

    • Immunology
    • Parasitology
    • Pathology

    Background:

    • Onchocerciasis is a filarial disease caused by Onchocerca volvulus.
    • Lymph node pathology is central to understanding disease progression and immune response.

    Purpose of the Study:

    • To investigate the cellular and immune responses within lymph nodes in patients with onchocerciasis.
    • To compare immune reactions in generalized versus localized forms of the disease, with and without diethylcarbamazine treatment.

    Main Methods:

    • Light and electron microscopy of lymph node biopsies.
    • Immunohistochemical staining (PAP) for cellular markers and immunoglobulins (IgE, IgG).

    Main Results:

    • Degenerated microfilariae were observed, surrounded by eosinophils and macrophages.

    Related Experiment Videos

  • Increased mast cells and plasma cells, producing IgE and IgG, were noted.
  • Germinal center hyperplasia and IgE deposition by dendritic reticular cells were characteristic findings.

    • Conclusions:

    • Both eosinophils and macrophages are involved in microfilariae clearance.
    • IgE and IgG play significant roles in the immune pathology of onchocerciasis.
    • Lymph node immune cell activity, particularly IgE production, is a hallmark of the disease.