[Development of MOF as result of DIC. Clinical and experimental studies]

Sixty three percent of 60 cases of clinically diagnosed Disseminated Intravascular Coagulation (DIC) developed to Multiple Organ Failure (MOF) and the mortality was high in the group which showed organ failure before the manifestation of DIC. The mortality of MOF cases was 91.6% and the presence of organ failure before or after DIC manifestation did not affect the mortality. Among 41 autopsy cases, microscopic examination showed pathohistological DIC in 19 cases even in basic lesion bearing cases without any clinical DIC signs (31.3%). Clinically and experimentally it was suggested that intrinsic and extrinsic endotoxin, namely, hepatic failure, infection etc. may play an important role in manifestation of DIC and development of MOF. Once DIC appears, hypercoagulability and hyperfibrinolysis will develop, then microthrombus in organs will appear in quite early phase of clinical course. Organ specificity and intraorganic specificity might be explained by anatomical factor and local fibrinolysis, etc.. In conclusion, the early detection of DIC and employment of protective treatment for organ failure are though necessary to improve prognosis.