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Related Experiment Videos

[Experimental ARDS and its prevention].

M Matsuda, M Takahashi

    Nihon Geka Gakkai Zasshi
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Disseminated intravascular coagulation (DIC) may trigger acute respiratory distress syndrome (ARDS) in surgical patients. Animal studies support this, showing preserved respiratory function when DIC was inhibited.

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    [WOUND CLOSURE METHODS FOR PREVENTION OF SURGICAL SITE INFECTION AND PATHOLOGIC SCARS－INCISION AND SUTURE METHODS FOR PREVENTION OF SSI, HYPERTROPHIC SCARS AND KELOID-].

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    [PREFACE TO “WOUND CLOSURE METHODS FOR PREVENTION OF SURGICAL SITE INFECTION AND PATHOLOGIC SCARS ― INCISION AND SUTURE METHODS FOR PREVENTION OF SSI, HYPERTROPHIC SCARS AND KELOID ―”].

    Nihon Geka Gakkai zasshi·2018
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    Area of Science:

    • Pulmonary Medicine
    • Hematology
    • Critical Care Medicine

    Background:

    • Acute Respiratory Distress Syndrome (ARDS) is a severe lung condition often seen post-surgery.
    • Disseminated Intravascular Coagulation (DIC) is a condition affecting blood clotting.
    • The relationship between ARDS and DIC in surgical patients requires further elucidation.

    Purpose of the Study:

    • To investigate the potential role of DIC as an underlying cause of postoperative ARDS.
    • To explore the correlation between respiratory function parameters and blood coagulation/fibrinolysis.
    • To assess the effect of prophylactic inhibition of coagulation on respiratory function in an animal model.

    Main Methods:

    • Retrospective analysis of 13 ARDS patients and 28 DIC patients from 1974-1980.

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  • Animal study in dogs correlating respiratory function with consumption coagulopathies.
  • Prophylactic administration of agents inhibiting platelets or coagulation in animal models.

    • Main Results:

    • All 13 ARDS patients exhibited DIC; ARDS was not present in all 28 DIC patients.
    • Respiratory function parameters paralleled changes in blood coagulation and fibrinolysis parameters.
    • Dogs treated prophylactically showed significantly preserved respiratory function compared to controls.

    Conclusions:

    • DIC may underlie and trigger ARDS in specific postoperative scenarios.
    • Findings suggest a causal link between DIC and the development of ARDS.
    • Further research is needed to clarify all contributing factors to this relationship.