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[Gastric mucosal changes induced by the augmented Histalog test: endoscopic and histopathological study]
Arquivos De Gastroenterologia
|July 1, 1983
Summary
Maximal doses of betazol hydrochloride (Histalog) did not cause significant gastric bleeding in volunteers. Brown secretions observed during Histalog tests are likely due to nasogastric tube trauma and mucosal congestion.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Betazol hydrochloride (Histalog) is used to assess gastric acid secretion.
- Potential effects of maximal Histalog doses on gastric mucosa require investigation.
Purpose of the Study:
- To evaluate the impact of maximal betazol hydrochloride doses on endoscopic and histologic gastric mucosa findings.
- To determine if Histalog administration causes significant gastric hemorrhage or mucosal damage.
Main Methods:
- Prospective study involving 11 volunteers.
- Gastroscopic examinations before and after maximal Histalog doses.
- Histologic analysis of gastric antrum and body mucosa.
Main Results:
- No mucosal alterations observed in 3/11 patients post-Histalog.
- Slight to moderate mucosal congestion in 6/11 patients.
- Scattered oozing bleeding points in 2/11 patients.
- No statistically significant difference in erosion, hemorrhage, or edema recurrence.
Conclusions:
- Maximal Histalog doses do not induce significant gastric mucosal hemorrhage.
- Observed brown discoloration in secretions is attributed to nasogastric tube trauma and Histalog-induced congestion.