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Blood-flow distribution in the mouse.

W T Stott, M D Dryzga, J C Ramsey

Journal of Applied Toxicology : JAT

|December 1, 1983

Summary

This study compared blood flow distribution in mice and rats using radiolabeled microspheres. While overall patterns were similar, mice showed higher bladder/large intestine flow and lower testicular flow compared to rats.

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Area of Science:

Physiology
Comparative Anatomy
Pharmacology

Background:

Understanding organ-specific blood flow is crucial for physiological and toxicological studies.
Rodent models are frequently used, necessitating comparative data between species.

Purpose of the Study:

To quantitatively compare blood-flow distribution in male B6C3F1 mice and Fischer 344 rats.
To identify species-specific differences in organ perfusion.

Main Methods:

Intracardial administration of 141Ce-radiolabeled microspheres in pentobarbital-anesthetized rodents.
Measurement of cardiac output proportion and blood flow per gram of tissue in 18 organs.
Comparative analysis between mice and rats.

Main Results:

General agreement in blood-flow distribution between mice and rats.
Mice exhibited higher relative blood flow to the bladder and large intestine compared to rats.
Mice showed lower relative blood flow to the testes compared to rats.
Rat liver and kidney received approximately double the blood flow per unit weight compared to mouse liver and kidney.

Conclusions:

Significant species-specific differences exist in the distribution of cardiac output and organ perfusion between mice and rats.
These findings are important for interpreting physiological and toxicological data derived from these models.

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