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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Peroxidase-dependent bioactivation and oxidation of DNA and protein in benzo[a]pyrene-initiated micronucleus formation.

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Related Experiment Video

Updated: Jul 10, 2026

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
09:45

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Published on: March 22, 2016

Brain aging and Alzheimer's disease.

D R Crapper, U DeBoni

    Canadian Psychiatric Association Journal
    |January 1, 1978
    PubMed
    Summary

    Senile dementia, often Alzheimer-type dementia, may stem from a combination of viral-like infections, immune system disorders, and environmental neurotoxins. This review examines evidence supporting this multifactorial hypothesis for dementia causes.

    Area of Science:

    • Neurology
    • Pathology
    • Immunology

    Background:

    • Senile dementia shares pathological hallmarks with presenile dementia of the Alzheimer type.
    • Alzheimer's disease is a leading cause of dementia, impacting millions globally.
    • Understanding the etiology of dementia is crucial for developing effective treatments.

    Purpose of the Study:

    • To review the evidence supporting a multifactorial hypothesis for Alzheimer-type dementia.
    • To explore the potential roles of viral-like infections, immune dysfunction, and environmental factors in dementia pathogenesis.
    • To synthesize current knowledge on the neuropathological basis of dementia.

    Main Methods:

    • Review of existing neuropathological and etiological studies on dementia.
    • Analysis of evidence linking specific agents to Alzheimer-type pathology.

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    Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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    Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
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    Published on: March 22, 2016

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    Published on: June 3, 2020

  • Integration of findings from infectious disease, immunology, and toxicology research.

    • Main Results:

    • Neuropathological findings in senile dementia are often indistinguishable from Alzheimer's disease.
    • The hypothesis suggests a synergistic interaction between viral-like agents, immune system disorders, and environmental neurotoxins.
    • Evidence supports the potential contribution of each factor to the disease process.

    Conclusions:

    • Alzheimer-type dementia may result from a complex interplay of at least three distinct processes.
    • Further research is warranted to elucidate the specific mechanisms and interactions of these factors.
    • This hypothesis provides a framework for future investigations into dementia prevention and treatment.