The pathology of idiopathic midline destructive disease (IMDD) in the eyelid

Subcutaneous eyelid and brow nodules were noted in a 25-year-old man who, at the age of 14 years, had developed the central facial and upper airway necrosis characteristic of idiopathic midline destructive disease (IMDD). One large nodule was located near the lateral canthus rather than a midline position. Insofar as we know, this report would constitute the first evidence of IMDD in the eyelids and brow in the absence of orbital disease.