The effect of low density lipoprotein on in vitro porcine endothelial cell reendothelialization

We have studied the effect of low density lipoproteins (LDL) on the ability of porcine thoracic aortic endothelial cells (EC's) to reendothelialize an in vitro experimental wound made in a confluent monolayer culture. Our results show that normolipidemic LDL enhances EC regeneration primarily by acting as a mitogenic agent on the cells in the migrating sheet of cells covering the denuded wound area. There was no evidence of LDL induced cytotoxicity in our study.