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Related Experiment Videos

Ocular fluorophotometry in normal subjects.

J J Kjaergaard

    International Journal of Microcirculation, Clinical and Experimental
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    In healthy individuals, increasing age is linked to fluorescein leakage into the vitreous humor. Blood pressure correlates with fluorescein in the aqueous humor, suggesting age and blood pressure influence ocular fluorescein levels.

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    Area of Science:

    • Ophthalmology
    • Physiology
    • Pharmacokinetics

    Background:

    • Fluorescein leakage into the vitreous is observed in conditions like diabetes and hypertension.
    • Understanding normal physiological determinants of fluorescein leakage is crucial for early detection of ocular diseases.

    Purpose of the Study:

    • To investigate factors influencing fluorescein leakage into the vitreous and aqueous humor in healthy subjects.
    • To determine the relationship between age, blood pressure, and intraocular fluorescein concentrations.

    Main Methods:

    • Intravenous fluorescein injection in 29 healthy males (aged 18-67).
    • Serial blood sampling for ultrafiltrable fluorescein measurement.
    • Ocular fluorophotometry to quantify fluorescein in vitreous and aqueous humor at 60 and 120 minutes.

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    Main Results:

    • Fluorescein concentrations in posterior vitreous, middle vitreous, and aqueous humor increased significantly from 60 to 120 minutes (p < 0.05).
    • Age correlated significantly with fluorescein concentrations in the posterior vitreous, middle vitreous, and aqueous humor at 60 minutes (p < 0.01).
    • Blood pressure correlated with aqueous humor fluorescein concentrations at 60 minutes (p < 0.05).

    Conclusions:

    • Age is a significant determinant of fluorescein accumulation in the vitreous humor of healthy individuals.
    • Blood pressure is associated with fluorescein levels in the aqueous humor.
    • These findings highlight age and blood pressure as key factors influencing ocular fluorescein dynamics in a healthy population.