Comparison of two continuous-flow cell separators.

Area of Science:

• Transfusion Medicine
• Hematology
• Biomedical Engineering

Background:

• Apheresis procedures are critical for obtaining specific blood components.
• Evaluating the efficiency of different blood cell processing systems is essential for optimizing component collection.

Purpose of the Study:

• To compare the performance of the IBM 2997 and Fenwal CS-3000 blood processors.
• To assess granulocyte and platelet yields and efficiencies during leukapheresis and plateletpheresis.

Main Methods:

• Two blood processors, IBM 2997 and Fenwal CS-3000, were evaluated under standardized conditions.
• Leukapheresis and plateletpheresis procedures were conducted, with data collected on cell yields and processing efficiencies.
• The Fenwal CS-3000 was tested at two different whole blood flow rates (50 ml/min and 60 ml/min).

Main Results:

• The IBM 2997 demonstrated significantly higher granulocyte yields (19.4 x 10^9) compared to the Fenwal CS-3000 (13.3-14.2 x 10^9) during leukapheresis.
• Platelet yields were comparable between the IBM 2997 (3.62 x 10^11) and Fenwal CS-3000 (3.15-4.3 x 10^11) during plateletpheresis.
• The IBM 2997 showed higher granulocyte collection efficiency (42.5%) than the Fenwal CS-3000 (30.5-39.2%).

Conclusions:

• The IBM 2997 processor is more effective for granulocyte collection than the Fenwal CS-3000.
• Both systems provide comparable platelet yields, suggesting suitability for platelet concentrate production.
• Flow rate adjustments on the Fenwal CS-3000 had a moderate impact on granulocyte and platelet yields and efficiencies.