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Related Experiment Videos

Contrast bone cement.

W L Bargar, K G Heiple, S Weber

    Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
    |January 1, 1983
    PubMed
    Summary
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    Adding methylene blue dye to bone cement enhances visualization without compromising biocompatibility or mechanical strength. Experienced surgeons can safely use this contrast bone cement for joint replacements.

    Area of Science:

    • Orthopedic Surgery
    • Biomaterials Science
    • Medical Device Engineering

    Background:

    • Acrylic bone cement is widely used in joint replacements.
    • Visualizing bone cement during revision surgery can be challenging.
    • Methylene blue dye is proposed as a visual contrast agent.

    Purpose of the Study:

    • To evaluate the effects of adding aqueous methylene blue dye to acrylic bone cement.
    • To assess the safety and efficacy of contrast bone cement in orthopedic procedures.

    Main Methods:

    • Three bone cement types were tested with added methylene blue dye.
    • Mechanical properties (strength, bending), biocompatibility, and setting times were evaluated.
    • Intrusion standards (ASTM F451) and viscosity were measured.

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  • Ease of removal and visualization were assessed in simulated and cadaveric models.

    • Main Results:

    • Leach out of dye was minimal (<2.0%) and undetectable after 8 days.
    • Biocompatibility was equivalent to standard white cement in rabbit models.
    • Mechanical strengths were largely unaffected, with a slight increase in 4-point bending for one type.
    • Working, dough, and setting times decreased by 30-150 seconds.
    • All contrast cements met ASTM F451 intrusion standards.
    • Viscosity remained suitable for bone penetration.

    Conclusions:

    • Contrast bone cement is safe and efficacious for initial and revision total joint replacements.
    • The dye addition does not significantly impair mechanical properties or biocompatibility.
    • Reduced working times necessitate use by experienced surgeons.