Preferential recognition of DNA by dimeric RNA polymerase II. An electron microscopic study

The forms of purified rat liver RNA polymerase II and their functions were analyzed by an electron microscopy. The author found that highly purified RNA polymerase II showed the following distinct two forms; dimeric and monomeric forms. Furthermore, the preferential binding to promotors of lambda dvl template by dimeric enzyme forms was observed. Finally, the role of dimeric RNA polymerase II on DNA template recognition was discussed.