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Analyses of risk factors of ischemic heart disease in diabetics--multivariate analyses
Insights
High triglyceride levels and hypertension are key risk factors for ischemic heart disease (IHD) in diabetes patients. These factors independently contribute to IHD, regardless of blood sugar control.
Area of Science:
- Cardiology
- Endocrinology
- Metabolic Syndrome
Background:
- Ischemic heart disease (IHD) is a major complication in diabetes mellitus.
- Identifying principal risk factors for IHD in diabetic patients is crucial for effective management.
Purpose of the Study:
- To confirm the principal risk factors for ischemic heart disease (IHD) in patients with non-insulin dependent diabetes mellitus.
- To investigate the correlation between ST-ECG findings and various clinical-laboratory parameters.
Main Methods:
- Multivariate analyses were performed on 70 non-insulin dependent diabetes mellitus patients.
- ST-ECG findings were categorized by IHD severity.
- Partial correlation analysis assessed relationships between ST-ECG and 18 clinical-laboratory variables.
Main Results:
- ST-ECG severity significantly correlated with triglyceride levels (r=0.455) and blood pressure (r=0.392).
- Blood pressure and triglyceride levels were sufficient for discriminating IHD presence.
- High triglyceride levels emerged as an independent risk factor for IHD in diabetes.
Conclusions:
- Elevated triglyceride levels and hypertension are significant risk factors for IHD in diabetic individuals.
- High triglyceride levels contribute to IHD independently of hyperglycemia control or other measured variables.
Abstract:
In order to confirm the principal risk factor of ischemic heart disease (IHD) in diabetes, multivariate analyses were performed. ST depression in electrocardiogram (ST-ECG) and 18 other clinical-laboratory findings (sex, age, duration of diabetes, blood pressure, cholesterol, HDL-cholesterol, triglyceride, etc.) were measured in 70 non-insulin dependent diabetes mellitus patients. ST-ECG findings were divided into five ranges as an index of the severity of IHD, based on the assumption that the degree of ST-ECG would provide a reasonable correlation to the grade of IHD. In partial correlation analysis, the degree of ST-ECG was significantly correlated both to the level of triglyceride (r = 0.455, p less than 0.001) and to blood pressure (r = 0.392, p less than 0.01), but not to the other 16 variables. Three selected variables (blood pressure, triglyceride and atherogenic index) were sufficient to provide a satisfactory discrimination between patients with and without IHD. Five selected variables (sex, blood pressure, triglyceride, atherogenic index and weight index) were sufficient for evaluation of regression. These results suggest that the high level of triglyceride and hypertension are essential risk factors of IHD in diabetes. It is noticeable that the high level of triglyceride is one of the independent risk factors of IHD in diabetes; it does not depend on the degree of control of hyperglycemia or on the other variables.