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Arteriosclerosis obliterans in Japanese diabetic patients
Insights
Arteriosclerosis obliterans (ASO) affects 1.9% of Japanese diabetic patients, particularly older men with hypertension. This study highlights risk factors and associations, noting lower ASO frequency in Japanese versus Western populations.
Area of Science:
- Vascular Medicine
- Diabetology
- Epidemiology
Background:
- Arteriosclerosis obliterans (ASO) is a significant complication of diabetes.
- Understanding ASO prevalence and risk factors in diverse populations is crucial for targeted interventions.
Purpose of the Study:
- To investigate the prevalence of lower extremity arteriosclerosis obliterans (ASO) in Japanese diabetic patients.
- To identify clinical factors associated with ASO in this population.
- To compare ASO frequency with Western diabetic patients.
Main Methods:
- Retrospective analysis of 1673 Japanese diabetic patients.
- Comparison with age- and sex-matched control patients.
- Examination of foot arterial pulses (A. dorsalis pedis) in 451 diabetic patients.
Main Results:
- ASO was identified in 1.9% of Japanese diabetic patients.
- Male sex, older age, hypertension, and neglected diabetes treatment were positively correlated with ASO.
- Proteinuria, cerebral vascular disease, and myocardial infarction were significantly associated with ASO.
- Absent A. dorsalis pedis pulse was observed in 6.4% and correlated with ASO signs/symptoms.
- ASO frequency appeared lower in Japanese compared to Western diabetic patients.
Conclusions:
- Male sex, older age, hypertension, and poor diabetes control are key risk factors for ASO in Japanese diabetics.
- Foot pulse examination is a valuable indicator for ASO.
- The prevalence of ASO in Japanese diabetic patients is lower than in Western populations.
Abstract:
Arteriosclerosis obliterans (ASO) of the lower extremities was found in 32 cases (1.9%) among 1673 Japanese diabetic patients. Comparison with age-and sex-matched control patients revealed that male sex, older age, hypertension and neglect of treatment of diabetes were positively correlated with ASO, but obesity, smoking and hyperlipidemia were not correlated with ASO. Proteinuria, cerebral vascular disease and myocardial infarction were significantly associated with ASO. The arterial pulses of the foot were examined in 451 diabetic patients. The pulse of A. dorsalis pedis was absent in 29 (6.4%) and was significantly related to the clinical signs and symptoms of ASO. The loss of the pulse of A. dorsalis pedis increased with age and was more frequent in men than in women. The results indicate a lower frequency of ASO in Japanese than in Western diabetic patients.