Diabetes in tropics--perspectives of research

HLA antigen studies indicate heterogeneity of allele of B locus and propedine factor based on racial differences, while confirming specificity of DR3-DR4 for IDDM. C-peptide reserve is indicative of some sparing of beta cell destruction due to pre-existing nutritional state with enzymatic modulations modifying ketosis in the atypical IDDM in North India. Specific diabetic vascular disease has lesser geographical predisposition though factors that promote its severity or restrain its progress are not well understood.