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Related Experiment Videos

Necrotizing enterocolitis in the asphyxiated full-term infant.

R N Goldberg, D W Thomas, F R Sinatra

    American Journal of Perinatology
    |October 1, 1983
    PubMed
    Summary

    Necrotizing enterocolitis in newborns is linked to severe perinatal asphyxia and hyperammonemia. Early identification of these clinical signs may improve outcomes with conservative management.

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    Area of Science:

    • Neonatal Medicine
    • Pediatric Gastroenterology

    Background:

    • Necrotizing enterocolitis (NEC) is a serious gastrointestinal condition in neonates.
    • Early-onset NEC requires prompt recognition and management strategies.

    Observation:

    • Five term infants presented with histologically confirmed NEC within the first five days of life.
    • Clinical presentation included grossly bloody stools and mucosal casts.
    • All infants experienced severe perinatal asphyxia with secondary hyperammonemia.

    Findings:

    • Three infants exhibited abnormal liver function studies.
    • A strong association was observed between NEC, perinatal asphyxia, and hyperammonemia.

    Implications:

    • Recognizing these clinical characteristics is crucial for early diagnosis of NEC.
    • Conservative management approaches may be beneficial for affected infants.

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