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Antigen Dd reactivity in selected diseases.

H Kaur, P K Shrivastava

    Acta Anthropogenetica
    |January 1, 1983
    PubMed
    Summary

    Antibodies against antigen Dd were lower in most diseases studied, including cirrhosis and cardiovascular diseases, but not in rheumatoid arthritis or breast cancer. This suggests antigen Dd-reactivity may be a useful biomarker for certain conditions.

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    Area of Science:

    • Immunology
    • Clinical Medicine
    • Biochemistry

    Background:

    • Antigen Dd-specific antibodies have been investigated for their potential role in various pathological conditions.
    • Understanding the distribution of these antibodies can provide insights into disease mechanisms and potential diagnostic markers.

    Purpose of the Study:

    • To investigate the prevalence of detectable antibodies against antigen Dd across a spectrum of human diseases.
    • To compare antigen Dd-reactivity in patients with specific conditions against healthy controls.

    Main Methods:

    • Serological analysis was performed to detect antibodies against antigen Dd.
    • The study included patients diagnosed with rheumatoid arthritis, goitre, nephrotic syndrome, cirrhosis, gastrointestinal tract diseases, neurological diseases, liver and gall bladder diseases, breast cancer, respiratory diseases, and cardiovascular diseases.
    • Comparisons were made with a control group.

    Main Results:

    • Significantly lower incidence of antigen Dd-reactivity was observed in patients with cirrhosis, gastrointestinal tract diseases, neurological diseases, liver and gall bladder diseases, respiratory diseases, and cardiovascular diseases compared to controls.
    • In contrast, antigen Dd-reactivity levels were comparable to controls in rheumatoid arthritis, breast cancer, and nephrotic syndrome.

    Conclusions:

    • The distribution of antibodies against antigen Dd varies significantly across different disease states.
    • A reduced presence of antigen Dd-reactivity is associated with several serious conditions, suggesting its potential as a biomarker.
    • Further research is warranted to elucidate the clinical significance of these findings.

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